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KMID : 0604620060130010077
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Dongguk Journal of Medicine
2006 Volume.13 No. 1 p.77 ~ p.82
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A Case of Therapeutic Experience with Low dose Thalidomide for Myelodysplastic Syndrome
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Lim Ji-Hyon
Hur Hee-Jin
Chae Seok-Lae
Kim Do-Yeun
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Abstract
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Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders. The recent therapeutic advances are intensive low dose chemotherapy, erythropoietin, colony-stimulating factors and new drugs. Thalidomide has demonstrated a considerable efficacy in MDS. We report a case of MDS in a 69-year-old man who presented with acute febrile neutrophilic dermatosis (Sweet’s syndrome). Initially, the prednisolone was administered as treatment of Sweet’s syndrome. Thalidomide was added to the patient with a 100 mg initial dose but the patient did not tolerate the side effects of fatigue and constipation. Maintenance with the tolerable dose of 50 mg resulted in transfusion independence and no recurrence of cutaneous lesions.
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KEYWORD
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thalidomide, myelodysplastic syndrome, Sweet’s syndrome
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